Premenstrual Syndrome ( PMS )               Explore Some More Xenoestrogens "What I learned from Theo Colborn"                       Explore Some More Xenoestrogens and PMS Tulane and Xavier University Tutorial on Xenoestrogens

Estrogen Use with Progesterone   Cut down and Eventually Stop Estrogen Use with Progesterone Women after menopause produce 40% of the estrogen that they did before menopause. Progesterone levels fall to less than 1% of premenopause levels. Progesterone resensitizes the body's cells to estrogen. So estrogen pills can be cut back and eventually stopped over a period of 3-6 months. Stopping estrogen pills suddenly ("Cold Turkey") will cause hot flashes.   by Elizabeth Smith, M.D. According to Dr. Lee, Theo Colborn, and other researchers, women in America and developed countries are getting too much estrogen. Where does this estrogen come from? First of all, before menopause the woman produces estrogen by the follicle on the ovary. Second, the woman produces estrogen herself before and after menopause in the body fat cells. Third, she may be taking estrogen by pill or by skin patch for hormone replacement or for birth control. Fourth, she may be getting estrogen effects from chemicals that mimic estrogens known as xenoestrogens. These xenoestrogens include estrogens fed to agricultural animals that we in turn eat, detergent break down products, plastic containers used for food and water, pesticides, and even spermicide found in condoms. A woman produces estrogen in mainly two places. The follicle on the ovary produces estrogen. The fat cells produce estrogen. The more fat you have, the more estrogen you produce. When women go through menopause (after age 50), their estrogen production goes down to 30%-50% of premenopause levels. However, progesterone production goes down to less than 1% of premenopause levels. A heavy set woman after menopause will actually produce more estrogen than a skinny woman before menopause. Usually, during premenopause (before age 30) multiple eggs get ready to ovulate and form follicles on the ovary. The follicles on the ovary produces estrogen. One follicle becomes dominant. That follicle ruptures, the egg is released, and all the other follicles become smaller and eventually disappear. The ruptured follicle is called the corpus luteum, and the ovary produces progesterone. Around menopause, perimenopause (ages 30 - 50), a woman may have periods, but not ovulate. During perimenopause, sometimes the dominant follicle DOES NOT rupture, the egg DOES NOT ovulate, the corpus luteum is NOT formed, and NO progesterone is produced. Thus, around the age of menopause, perimenopause, estrogen is produced, but LITTLE or NO progesterone is produced. This is known as an anovulatory cycle. Thus, around the time of menopause (perimenopause) and after menopause progesterone levels drop tremendously. However, during perimenopause estrogen levels do NOT drop. Thus, this is a time in life where the woman is naturally estrogen dominant and Premenstrual Syndrome ( PMS ) are stimulated to grow. After menopause, estrogen levels drop to 40% to 60% of premenopause levels produced by the body fat. Progesterone levels remain at less than 1%. I Started Progesterone and Now I Feel Worse. Why? Constant estrogen ingestion in the form of pills or xenoestrogens causes the estrogen receptors to down regulate. In other words, the woman's body has so much estrogen that the estrogen receptors become less sensitive. A good analogy would be when you enter a noisy room. When you first enter the room you notice the noise. However, after being in the noisy room for a while, the noise becomes less noticeable. Your ears become less sensitive to the noise. In effect, your ears down regulate. Thus, if you take estrogen supplements or get doses of xenoestrogens, after a while, your body will become less sensitive to estrogens. This is because your body has too much estrogen, and the body tries to become less sensitive. However, when you take progesterone the estrogen receptors are resensitized to their original sensitivity. In other words, when you begin to take progesterone, you regain your original sensitivity to estrogen. "When you begin to take progesterone, you regain your original sensitivity to estrogen." The solution is to cut back on the dose of estrogen. Dr. Lee recommends immediately cutting back the dose to 1/2 of the normal dose. He recommends stopping the estrogen dose altogether over a period of 3-6 months phasing out the dose of estrogen slowly.  Also, CUT OUT the xenoestrogens in your environment. He maintains that women's bodies produce enough estrogen already. See the graph above! Some patients have enthusiastically have stopped their estrogen suddenly - cold turkey. These "Cold Turkey" patients frequently experience Hot Flashes. Phasing out the estrogen gradually prevents Hot Flashes. Summary In summary, women already get too much estrogen. They produce estrogen themselves from the follicles on their ovaries and from their fat cells premenopause and perimenopause. After menopause, the woman's fat cells produce estrogen. Women also get estrogen from birth control pills and hormone replacement therapy. Women get estrogen from chemicals that mimic estrogen know as xenoestrogens. These chemicals are present in everyday materials previously thought to be inert such as detergent break down products, plastics used to store water, varnish in food cans used to prevent the "metal" taste, pesticide, and even spermicide. In summary, taking progesterone will resensitize the estrogen receptors so that your body becomes more sensitive to estrogen supplements or xenoestrogens. The solution is to immediately cut the dose of estrogen to 1/2, and DISCONTINUE estrogen supplements altogether over a period of 3-6 months. Cut out as much xenoestrogen intake as possible. The body's internal production of estrogen is more than sufficient.  Also, CUT OUT the xenoestrogens in your envrionment.  Stopping your estrogen pills suddenly or "Cold Turkey" will result in undesirable HOT FLASHES!